Sawyer at the department of surgery, university of virginia health system, box 800709, charlottesville, va 229080709. Ticagrelor versus clopidogrel in patients with acute coronary. The cure trial was found to be of high quality jadad score 55. In an openlabel, singlegroup study in which followup is ongoing at three south african sites, we investigated treatment with three oral drugs. Publication of the medalist trial results in a journal of such eminence will certainly help to.
Use of vibrio cholerae vaccine in an outbreak n engl j med 370. Initiation strategies for renalreplacement therapy in the. Antithrombotic therapy for atrial fibrillation with stable coronary. The new england journal of medicine 2086 n engl j med 355.
Partial oral versus intravenous antibiotic treatment of. New tb clinical trials on the horizon 2 current state of dstb treatment combination therapy essential to prevent emergence of resistance current 6month regimen validated in clinical. Glecaprevirpibrentasvir for 8 or 12 weeks in hcv genotype. Pci cure is a substudy of the clopidogrel in unstable angina to prevent recurrent events cure study. The trial was sponsored by the netherlands heart institute, biotronik, and astrazeneca. Concluded transfusion better than observation for secondary prevention. Canagliflozin and cardiovascular and renal events in type. Assistant professor, division of infectious diseases.
The purpose of the cure trial, published in 2001, was to explore whether the addition of clopidogrel, a thienopyridine class antiplatelet agent, could further reduce the risk of recurrent. Pci cure was a prospectively designed study of patients undergoing pci who were randomised to doubleblind therapy with clopidogrel or placebo in the clopidogrel in unstable angina to prevent recurrent ischaemic events cure trial. Reblozyl is not approved to treat mds in any geography. Abstract background there are limited data from randomized trials evaluating the use of antithrombotic therapy in patients with atrial fibrillation. Ccure clinical trial full text view clinicaltrials. The new england journal of medicine 1996 n engl j med 372. Trial design and oversight the partial oral treatment of endocarditis poet trial was a nationwide investigatorinitiated, multi center, randomized, unblinded, noninferiority trial performed at cardiac centers in denmark. Stop trialn for patients with abnormal tcd, transfusion is superior to no. Kaitlin rainwaterlovett, phd, mph, priyanka uprety, and deborah persaud, md johns hopkins university martha sichonecameron, community lead december 2014 the hiv cure training curriculum is a collaborative project aimed at making hiv cure research science accessible to the community and the hiv research field. Nejm landmark trial repository prepared 2122020 by. The new england journal of medicine 302 n engl j med 370. The new england journal of medicine downloaded from at uwmadison on october 31, 20.
Antithrombotic therapy after acute coronary syndrome or. The antiplatelet agent clopidogrel has beneficial effects in patients with acute coronary syndromes without stsegment elevation. Alirocumab in patients with recent acute coronary syndrome. The effects of normal as compared with low hematocrit.
The results are published in the august 18, 2001 issue of the lancet, to coincide with the. Backgroundduring primary percutaneous coronary intervention pci, manual thrombectomy may reduce distal embolization and thus improve. The trial also included a per protocol analysis which excluded those who received openlabel clopidogrel prior to pci. Lipid management for the prevention of atherosclerotic. The primary and secondary endpoints are discussed as well as inclusion and exclusion criteria.
Trial of transplantation of hcvinfected kidneys into. Randomized, controlled trials in health insurance systems. Make pdf booklets, impose nup pages, combine pdf files, add watermarks, edit forms, add comments, add headers and footers, rearrange pages, security, digital signature, scan, ftp and much more. The authors vouch for the completeness and accuracy of the data and for the adherence of the trial to the protocol, available with the full text of this article at. The 2009 platelet inhibition and patient outcomes plato trial randomized 18,624 patients with acs 37. Azithromycin versus doxycycline for urogenital chlamydia. Acute bacterial sinusitis in children is diagnosed on the basis of the history, with the use of the. This nejm publication recognizes the importance and robustness of the medalist study, as well as the. It might surprise you to know that diabetes has been diagnosed as a disease since 1550 b. Notable articles of 2015 the new england journal of medicine. Aspirin in patients undergoing noncardiac surgery nejm 370. Randomized trial of primary pci with or without routine manual. Supportive therapy is the cornerstone of treatment.
Finally, the studies had a single test of cure within 2 to 5 weeks after treatment but did not have a repeat test at a later time to evaluate pa. Mortality was similar after the two procedures but patients treated with pci had higher rates of nonprocedural myocardial infarction and repeat revascularisation. New england journal of medicine challenged our ways of thinking. The new engl and journal of medicine 2488 n engl j med 363. Apalutamide treatment and metastasisfree survival in.
In revascularisation of left main coronary artery disease, pci was associated with an inferior clinical outcome at 5 years compared with cabg. Oacalone openlabel trial comparing oral anticoagulation with. Jul 19, 2016 the trial aims to include 438 participants who are centrally randomized to one of the two treatment groups in a 1. At a mean followup of 9 months, dual antiplatelet therapy was associated with a significant reduction in.
An independent data and safety monitoring board provided external oversight to ensure the safety of the trial participants. Trial of transplantation of hcvinfected kidneys into uninfected recipients. A recombinant vesicular stomatitis virus ebola vaccine. Paul myles chair, rinaldo bellomo, tomas corcoran, chris christophi. The new england journal of medicine 2 n enl med nemor i ntravenous alteplase administered within 4. Listing a study does not mean it has been evaluated by the u. Nejm may 21, 2009 no difference in 30d deathmithrombosis between routine early use of eptifibatide and provisional use at the time of pci. The clopidogrel in unstable angina to prevent recurrent events cure trial investigators are listed in the appendix. Minimally invasive versus abdominal radical hysterectomy. Use of vibrio cholerae vaccine in an outbreak in guinea. C cure clinical trial the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. A trial of lopinavir ritonavir in adults hospitalized with severe covid19. Cure treated patients 312 months, with mean duration 9 months credo treated patients 12 months, but only 6264% of patients treated a full 12 months 2007 aha scientific statement based on somewhat nebulous conclusions from fda meeting and modest, nonrandomized and observational data nothing magical about 12 months or 365 days. The new england journal of medicine is a publication of nejm group, a division of the massachusetts medical.
Doxycycline for chlamydia infection u rogenital chlamydia trachomatis in fection is the most prevalent bacterial. A randomized trial of treatment for acute anterior. Prasugrel effient vs clopidogrel plavix in patients with acs 1 trial to. Notable articles of 2015 the new england journal of. Ranibizumab and bevacizumab for neovascular agerelated nejm. The new england journal of medicine m etastases are a major cause of complications and death among men with prostate cancer. Trial design and oversight our trial, the saline against lactated ringers or plasmalyte in the emergency department salted trial, was a singlecenter, pragmatic, unblinded, multiplecrossover trial. In a prospective study, 697 patients with acute coronary syndromes underwent threevessel coronary. Participants in canvas were randomly assigned in a 1.
At 1 year, the mean systolic blood pressure was 121. Supportive and attentive health care preferably with effective medications, but even without legitimately creates. Background ticagrelor is an oral, reversible, directacting inhibitor of the adenosine diphosphate receptor p2y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogre. Trial oversight the established status epilepticus treatment trial esett was an investigatorinitiated, multicenter, randomized, blinded, comparativeeffectiveness trial of levetiracetam.
The primary endpoint of the trial is overall survival assessed with a minimum followup of 36 months. Cure was designed to evaluate if clopidogrel would further improve outcomes from acs when added to asa. An openlabel pilot trial involving 10 patients shows that hepatitis c virus genotype 1infected kidneys transplanted into hcvnegative recipients, followed by directacting antiviral therapy, can result in excellent allograft function with cure of hcv infection. Trial oversight the established status epilepticus treatment trial esett was an investigatorinitiated, multicenter, randomized, blinded, comparativeeffectiveness trial of levetiracetam, fosphenytoin, and valproate for the treatment of patients with established status epilepticus in the emergency department. Treatment of highly drugresistant pulmonary tuberculosis nejm. Jan 09, 2020 it is truly an honor to see work that began in acceleron laboratories more than a decade ago and advanced successfully through a collaboration with bristolmyers squibb now highlighted in the new england journal of medicine, said habib dable, president and chief executive officer of acceleron. Optimal antithrombotic treatments in patients with atrial fibrillation. Background clinical trials have established the efficacy of ranibizumab for the treatment of neovascular agerelated macular degeneration. Correction of anemia with epoetin alfa in chronic kidney. New england journal of medicine publishes results of pivotal. Sit trial debaun nejm 2014 n randomized scd 515 yo with silent stroke to receive regular blood transfusions or standard care observation group. Balanced crystalloids versus saline in critically ill adults. The clopidogrel in unstable angina to prevent recurrent events cure trial randomized 12,562 patients with uanstemi to either dual antiplatelet therapy with aspirin plus plavix or to aspirin alone immediately upon presentation. Now includes the form filler for free oneoff license fee.
In a randomized, noninferiority trial published in nejm, li et al. A randomized trial of intensive versus standard bloodpressure. A new nihfunded study reported in the new england journal of medicine nejm gives some hope for the use of a combination of a specific type. Is intensive glucose control with a gliclazide based regimen better than standard glucose control with a nongliclazide based regimen in high risk, but not too hard to control t2dm. Coronary angiography after cardiac arrest without st. A trial of darbepoetin alfa in type 2 diabetes and chronic. The results of the clopidogrel in unstable angina to prevent recurrent events cure study aug. The sponsors of the trial had no role in the design or monitoring of the trial. Stem cells for scleroderma, new nejm article reports promise. In the clopidogrel in unstable angina to prevent recurrent events trial cure, investigators evaluated the effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes acss without stsegment elevation. Pci was performed after randomization at the discretion of the local investigator. Importantly, these data helped with the conundrum of treating prostate cancer.
In an openlabel, phase 3 trial, we randomly assigned 861 patients with previously untreated advanced clearcell renalcell carcinoma to receive pembrolizumab 200 mg intravenously once every 3 weeks plus axitinib 5 mg orally twice daily 432 patients or sunitinib 50 mg orally once daily for the first 4 weeks of each 6week cycle 429 patients. A trial on peanut allergy, published in a trial on peanut allergy, published in february, indicates that allergen avoidance. Hrombosis caused by a ruptured or eroded atherosclerotic plaque is the usual underlying mechanism of acute coronary syndromes. When no cure is available an inevitable occurrence at some points medicines ultimate mission is to relieve unnecessary suffering. Cutepdf convert to pdf for free, free pdf utilities. The cure for cholera the new england journal of medicine. Percutaneous coronary angioplasty versus coronary artery. This policy may be difficult to implement in other health systems, but imagine what prog1. Effects of pretreatment with clopidogrel and aspirin followed. Master protocols to study multiple therapies, multiple.
However, the risk of major bleeding is increased among patients treated with clopidogrel. Ticagrelor with or without aspirin in highrisk patients. Dolutegravir plus two different prodrugs of tenofovir to. The new england journal of medicine 1998 n engl j med 375. Themis is a randomized, doubleblind, placebocontrolled trial of ticagrelor versus placebo, on top of lowdose 75 to 150 mg aspirin. Balanced crystalloids versus saline in noncritically ill. All the authors vouch for the adherence of the trial.
The clopidogrel in unstable angina to prevent recurrent. A prospective naturalhistory study of coronary atherosclerosis. The new england journal of medicine 2 n engl j med t he current ebola virus disease evd outbreak has resulted in more than 24,000 cases and 10,000 reported deaths as of. Make pdf booklets, impose nup pages, combine pdf files, add watermarks, edit forms, add. Randomized trial of three anticonvulsant medications for. At least seven new drugs approved in the last ten years most important and revolutionary are the socalled novel agents proteosome inhibitors. Topline results alirocumab in patients after acute coronary syndrome. Methods study subjects in this randomized, prospective, openlabel trial, we studied. A collection of articles selected by nejm editors new england. The purpose of the cure trial, published in 2001, was to explore whether the addition of clopidogrel, a thienopyridine class antiplatelet agent, could further reduce the risk of recurrent ischemic events in patients suffering from acs without stelevation. At 12 months, the ticagrelor group had lower rates of cv death, mi, or stroke than clopidogrel 9. The new england journal of medicine 332 n engl j med 363.
Trial design the trial was a phase 3, multicenter, randomized trial with the primary objective to evaluate the hypothesis that laparoscopic or robotassisted radical hysterectomy minimally. Effects of clopidogrel in addition to aspirin in patients. Original article from the new england journal of medicine glecaprevirpibrentasvir for 8 or 12 weeks in hcv genotype 1 or 3 infection. In a pragmatic, clusterrandomized, multiplecrossover trial conducted in five inten sive care units at an academic center, we assigned 15,802 adults to receive saline 0. A randomized trial of intraarterial treatment for acute. Patients were eligible for the study if they had been hospitalized within 24 hours after the onset of symptoms and did not have stsegment elevation. The new england journal of medicine is a publication of nejm group, a division of. From the division of infectious diseases, department of pediatrics, university of wisconsin school of medicine and public health, madison. Acute bacterial sinusitis in children university of chicago. We conducted a randomized trial comparing oral azithromycin with doxycycline.
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